Based on over 10 years biotechnology research experience, Beacle developed SARS-COV-2 related products.
SARS-COV-2 is a virus having an envelope structure. Several proteins including Spike (S) proteins are displayed on the envelope, and in the envelope nucleus (N) protein make a complex with its RNA gene. The infection is revealed to start form the binding of S protein’s SB domain to ACE2 receptors of host cells and subsequent viral enters into host cells through endocytosis. Viral RNA is then released into cells by the aid of S protein’s S2 domain through membrane fusion system. N protein is the most abundant protein of SARS-COV-2 and highly immunogenic, and infected human often shows high antibody to N proteins. N protein is composed of three domains, called N terminus domain (NTD) related with RNA binding, C terminus domain (CTD) related with formation of complexes, and liner region of the two domains which is related with phosphorylation. Many vaccines are developed against SARS-COV-2 infection, and all of them utilizes S protein as the target molecule.
1. SARS-COV-2 antigens.
1) N proteins
NTD: N terminus domain of N protein produced in E. coli. Two types of proteins (thioredoxin-his tag and non-tag) are available.
CTD: C terminus domain of N protein produced in E. coli. Two types of proteins (thioredoxin-his tag and non-tag) are available.
full length N proteins: full length N protein produced in E. coli. In addition to the original Wuhan type, N proteins of 4 mutants, British, Brazil, South Africa, and India types are available.
For detail see datasheet
2. Anti-SARS-COV-2 antibody quantitative ELISA kit
1) Anti-N protein antibody ELISA kit
Antibodies that binds to full length N proteins are quantitatively measured by the kit using attached standard antibody. The kit utilizes our original antibody detection probe and highly sensitive.
For detail see datasheet(in preparation)
|product #||product name||Content||Price|
|BCL‐CON-F01||SARS-COV-2 Full length-tag||100μg||80000円|
|BCL‐CON-F02||SARS-COV-2 Full length||100μg||85000円|
|BCL‐COK-NA01||Anti-N protein antibody quantitative ELISA kit||96 assay||available soon|
Manual and MSDS